Omics · study · 2026
Histone chaperon ASF1B recruits distinct epigenetic factors in regulation of histone variant H3.3 during the fetal and adult erythropoiesis II
Listed in NCBI GEO
To gain insight into ASF1A, ASF1B and HIRA function during erythropoiesis, RNA-seq was performed in murine erythroleukemia (MEL) cells, human umbilical cord-derived progenitor erythroid 2 (HUDEP2) cells and human CD34+ erythroid progenitor cells.
Description
Notably, depletion of ASF1A, ASF1B and HIRA with/without DMSO induction significantly reduced the expression of genes associated with erythroid differentiation. Meanwhile, depletion of ASF1A and ASF1B in HUDEP2 cells as well as depletion of ASF1B in CD34+ cells significantly reduced the expression of genes associated with erythroid differentiation.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE285nnn/GSE285838 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE285838 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1206179 ncbi.nlm.nih.gov/bioproject/PRJNA1206179 ↗
project · from NCBI GEO
- PubMed 42100853 pubmed.ncbi.nlm.nih.gov/42100853 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE285838 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |