Mapping the effects of plasma-mediated rejuvenation across brain regions

However, scalable, molecular tools to profile this process are currently missing, hampering efforts to translate these findings into clinical applications. Here, we leverage the advents of brain-region-specific transcriptomics as a readout of cellular deterioration accompanying the aging process.

Profiling expression shifts in cortex (Cor), hippocampus (Hip) and Cerebellum (Ceb) we identify the region-specific responses to young plasma. This atlas of brain rejuvenation supports the identification of potential mediators of plasma-derived factors, and provides the basis for finding a minimal gene expression set - a signature - to sufficiently quantify brain rejuvenation.