Omics · study · 2026
DHX9 sustains hematopoietic stem cell function in cooperation with H3 acetylation [CUT&Tag]
Listed in NCBI GEO
We identify DHX9 as critical regulator for HSCs maintenance and it's associated with H3 acetylation, particularly at K27.
Description
To elucidate the mechanisms underlying the role of Dhx9 deficiency and H3K27ac in hematopoiesis, we performed CUT&Tag on lineage nagative cells from DHX9 hematopoietic cell-specific conditional knockout mice(cKO) and those from WT mice.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE278nnn/GSE278361 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE278361 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1166878 ncbi.nlm.nih.gov/bioproject/PRJNA1166878 ↗
project · from NCBI GEO
- PubMed 41650960 pubmed.ncbi.nlm.nih.gov/41650960 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE278361 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |