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Data · dataset · 2026

<p>Permutation-based calibration of cross-disease module matching.</p>

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<p>(A) Null distribution of the total number of criteria-positive OA-OP module pairs across 10,000 block-stratified module-label permutations preserving each block-specific gene universe and exact module sizes.

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The orange line indicates the observed count of 234, the dashed blue line indicates the null mean of 254.83, and blue shading indicates the 95% null interval of 242–267. The upper-tail empirical P value was 0.9995.

(B) Observed and null-calibrated counts for the nine OA-OP block combinations. Blue points and horizontal intervals indicate null means and 95% intervals; orange points indicate observed counts. Numbers indicate pair-specific correspondences with empirical FDR < 0.05.

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(C) Pair-specific empirical FDR across all 464 tested module combinations. Cells are colored by pair-level -log10(empirical FDR) for the 234 criteria-positive pairs; white cells did not meet the deterministic criteria. Black dots indicate the 53 pairs with empirical FDR < 0.05.

OA, osteoarthritis; OP, osteoporosis; FDR, false discovery rate.</p> <p>(TIF)</p>

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UCL Research Data Repositoryoai:figshare.com:article/3404858013 d agoJSON v1
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