Omics · study · 2026
Toxicological assessment of microplastic exposure on Rats
Listed in NCBI GEO
Microplastics, derived largely from degraded household and commercial plastics, have become a pervasive environmental concern, and may pose health risks resulting from ingestion and accumulation in living organisms.
Description
Polyethylene terephthalate (PET) microplastics, commonly found in consumer products such as plastic bottles and clothing, have been detected in human arteries and brains among other tissues—although their health impacts remain unknown.
This study aimed to evaluate sex-based differences in biological effects of a single oral gavage of PET microplastics Sprague-Dawley rats. Adult rats (3 mo) were exposed to PET through oral gavage for approximately 18.5 hr. At the completion of the exposure, rats were evaluated for changes in metabolic rate and blood markers of inflammation, metabolism, stress, and stress.
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Rats were euthanized and liver, stomach, and duodenal tissue were used to identify exposure dependent changes in gene expression. Minor sex-dependent differences were observed in metabolic rate, metabolic biomarkers, and blood platelet concentration. Consistent with this, RNA-seq analysis identified few differentially expressed genes in either sex.
No overlap among DEGs across all three tissues was observed between males and females. Together these results suggest that even in short term exposures PET alters diverse endpoints across tissues in a sex-dependent manner. Though effects were relatively minor, evaluating the effects of PETs in chronic studies is merited.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE303nnn/GSE303044 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE303044 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1293402 ncbi.nlm.nih.gov/bioproject/PRJNA1293402 ↗
project · from NCBI GEO
- PubMed 41853959 pubmed.ncbi.nlm.nih.gov/41853959 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Rattus norvegicus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE303044 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10116 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |