A polyphenol-rich extract recovered from an industrial byproduct regulates the intestinal microbiota and restricts enteric parasite infection

Effects on the gut microbiome were dependent on infection status. In uninfected animals, the extract significantly reshaped the gut microbiome by expanding a broad range of short-chain fatty acid (SCFA)-producing bacteria. However, during H. polygyrus infection, its modulatory effect on the microbiome was markedly diminished concomitant with an extensive increase in the abundance of the Lactobacillaceae and Enterobacteriaceae families in infected mice.

However, the extract reduced the relative abundance of Clostridiaceae during infection, suggesting a role in restoring gut homeostasis by counteracting parasite-induced expansion of potentially pathogenic bacteria. Collectively, these findings demonstrate that byproducts from the biorefining industry can be repurposed as functional food components with the potential to limit enteric infection and inflammation.