Omics · study · 2026
Id2 promotes sepsis-induced tissue damage by mediating macrophage metabolic reprogramming via Pkm2 [CUT&Tag]
Listed in NCBI GEO
We constructed a single-cell atlas of multi-tissue macrophages of mice in steady-state and sepsis, comparing the characteristics of macrophages of different tissues at both the cellular and genetic levels.
Description
After sepsis,we revealed a consistent glycolytic shift in macrophages, with Pkm2 and Id2 emerging as key genes in this process. Among them, through ATAC-seq and CUT&Tag we demonstrated that Id2 mediates the metabolic reprogramming of macrophages by regulating the chromatin accessibility of Pkm2 with Tcf4 act as a mediator.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE312nnn/GSE312986 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE312986 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1378060 ncbi.nlm.nih.gov/bioproject/PRJNA1378060 ↗
project · from NCBI GEO
- PubMed 42695041 pubmed.ncbi.nlm.nih.gov/42695041 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE312986 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |