Omics · study · 2026
CD47 Blockade Reprograms the Monocyte-Macrophage Axis to Promote Inflammation Resolution in Atherosclerosis
Listed in NCBI GEO
Targeting the CD47-SIRPα axis, a dominant “don’t-eat-me” signal, via innate immune checkpoint inhibition limits atherosclerosis in preclinical models and early clinical studies.
Description
However, how this pro-efferocytic intervention reshapes the immune landscape of atherosclerotic lesions remains incompletely understood. Using single-cell transcriptomics, we comprehensively characterized the transcriptomic profile of mouse CD45+ aortic leukocytes by CD47 blockade.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE319nnn/GSE319762 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319762 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1425059 ncbi.nlm.nih.gov/bioproject/PRJNA1425059 ↗
project · from NCBI GEO
- PubMed 42094377 pubmed.ncbi.nlm.nih.gov/42094377 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE319762 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |