Omics · study · 2026
Transcriptomic profiling of MIA PaCa-2 cells treated with hydroxyprogesterone caproate
Listed in NCBI GEO
Pancreatic ductal adenocarcinoma (PDAC) remains refractory to targeted therapy.
Description
This RNA-sequencing study characterizes transcriptional changes in the human PDAC cell line MIA PaCa-2 following treatment with hydroxyprogesterone caproate (HPC). Comparison with DMSO vehicle-treated cells was used to identify HPC-responsive genes and pathways.
The transcriptomic analysis supported repression of cell-cycle, DNA-replication and pyrimidine-metabolism programs and contributed to investigation of the COP1-CEBPB-CDA mechanism underlying the anti-PDAC activity of HPC.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE338nnn/GSE338233 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE338233 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1492886 ncbi.nlm.nih.gov/bioproject/PRJNA1492886 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE338233 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |