Omics · study · 2026
Prophylactic and therapeutic itaconate treatment alleviates COVID-19-associated lung injury
Listed in NCBI GEO
Itaconate (ITA), an immunomodulatory metabolite with known anti-inflammatory properties, has underexplored therapeutic and prophylactic potential against coronavirus disease 2019 (COVID-19).
Description
Metabolomic analyses revealed that intranasal administration of a dNS1-RBD vaccine (a live-attenuated, cold-adapted influenza virus-based vaccine deficient in nonstructural protein 1 [NS1] and expressing the SARS-CoV-2 receptor binding domain (RBD)) upregulated ITA levels, prompting further exploration of its immunomodulatory role.
This multiomics study investigates the therapeutic and prophylactic potential of ITA against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced acute lung injury (ALI) using an interanimal transmission hamster model that mimics the predominant natural route of SARS-CoV-2 infection. Both prophylactic and therapeutic ITA treatments significantly mitigated weight loss and improved lung pathology in infected hamsters.
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Transcriptional profiling demonstrated that ITA downregulated immune activation pathways while enhancing fatty acid β-oxidation (FAO)-related genes, correlating with reduced pro-inflammatory cytokine/chemokine release.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE304nnn/GSE304799 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE304799 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1302763 ncbi.nlm.nih.gov/bioproject/PRJNA1302763 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE304799 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |