Omics · study · 2026
NCOR1 alleviates osteoarthritic cartilage degradation in vivo and in vitro via ERRα-RASSF1-Hippo/YAP pathway
Listed in NCBI GEO
The significant socioeconomic burden of osteoarthritis (OA) coupled with limitations of current treatments underscores the critical need for discovering novel therapeutic target or molecular mechanisms that can slow or halt OA progression.
Description
Herein, we first explored the function and specific mechanism of nuclear receptor corepressor 1 (NCOR1) on OA in vivo and in vitro. Our study confirmed that NCOR1 expression was significantly decreased in IL-1β induced chondrocytes and OA cartilage.
NCOR1 overexpression suppressed IL-1β induced ECM degradation and apoptosis in vitro. Whereas NCOR1 knockdown exacerbated it. NCOR1 overexpression or knockdown in vivo alleviated or exacerbated DMM-induced osteoarthritic cartilage degradation.
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NCOR1 interacts with ERRα, thus inhibiting the transcription of RASSF1 gene and Hippo/YAP pathway. Inhibition of the NCOR1-ERRα-RASSF1-Hippo/YAP pathway by LPA or XCT790 demonstrated to alleviate DMM-induced and IL-1β induced OA models in vitro and in vivo. In conclusion, NCOR1 can alleviate osteoarthritic cartilage degradation in vivo and in vitro via ERRα-RASSF1-Hippo/YAP pathway.
Our work identified a novel and valuable therapeutic target for OA, thereby offering a better understanding of OA pathogenesis and a potential new treatment modality.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE344nnn/GSE344539 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE344539 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1516027 ncbi.nlm.nih.gov/bioproject/PRJNA1516027 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE344539 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |