Omics · study · 2026
Tracing the origins of de novo coronary collateral formation in cardiac repair [CUT&RUN]
Listed in NCBI GEO
Coronary collateral arteries have been proposed to form de novo through artery reassembly, a process in which arterial endothelial cells (ECs) migrate away from pre-existing arteries and reassemble into new arteries.
Description
Using genetic tools that trace arterial ECs, we found that their contribution to collateral is minor. Dual genetic lineage tracing reveals that capillary ECs, rather than arterial ECs, serve as the major building blocks for de novo collaterals.
The capillary-to-collateral conversion is functionally crucial for cardiac repair. In addition, transient Vegfa expression via modified mRNA markedly promoted collateral formation. Mechanistically, VEGF drives arterialization by regulating HES1 transcription through YY1/SETD1A-mediated H3K4 trimethylation.
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Collectively, these findings redefine the cellular origin and mechanism of de novo coronary collateral formation and highlight its role in facilitating efficient cardiac repair.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE334nnn/GSE334830 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334830 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1476575 ncbi.nlm.nih.gov/bioproject/PRJNA1476575 ↗
project · from NCBI GEO
- PubMed 42623479 pubmed.ncbi.nlm.nih.gov/42623479 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Heart 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE334830 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[anatomy].local:anatomy:heart | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |