mRNA-seq profiles of porcine ovarian mural granulosa cells from lactational full-fed and restricted-fed sows at two days post-weaning

In total, 2,282 differentially expressed genes (DEGs) were identified, of which 1,531 were upregulated and 751 were downregulated in RES. The most enriched pathway was the cell cycle.

Key cell cycle regulators and proliferation markers were upregulated, while differentiation markers were downregulated in RES. Several members of the insulin growth factor binding proteins (IGFBP) family, especially IGFBP7, were strongly correlated with FOXO1, CDKN1A (P21), most cell cycle-related genes, and follicle size exclusively in RES sows, but not in FF sows.