Single-Atom Nickel-Catalyzed C–H Amidation of Pyridine and Quinoline N‑Oxides

Two one-pot synthetic routes starting from commercially available quinoline were also designed, enabling the flexible preparation of both 2-acetamidoquinoline N-oxides and the pharmaceutically relevant 2-aminoquinoline scaffolds.

The single-atom nickel catalyst showed good stability, recyclability, and operational simplicity, while EXAFS analysis revealed a well-defined Ni–N₄ coordination environment. A hot filtration experiment confirmed the heterogeneous nature of the catalytic system. This work provides a practical approach to the 2-acetamidoquinoline N-oxide and further illustrates the utility of heterogeneous nickel catalysis in C–H functionalization reactions.