A “Claw-Capture” Multiplex Electrochemical Sensing Platform for Ultrasensitive and Hierarchical Detection of Hg(II) Based on Nanochannel-Confined Hollow Ce(III)-MOF Nanofibers Coupled with l‑Cysteine

The multiplex electrochemical sensing platform was fabricated based on nanochannel-confined hollow Ce(III)-MOF nanofibers coupled with l-cysteine (l-Cys), which can detect Hg(II) in environmental wastewater and complex serum samples with high sensitivity and a large-span concentration.

The uniformly ordered microporous hollow Ce(III)-MOF nanofibers not only exhibit excellent anti-interference and antifouling properties through electrostatic and spatial repulsion, but also the spontaneous cycling of Ce(III)/Ce(IV) based on the strong coordination effect between l-Cys and Ce(III) and the strong covalent bond between l-Cys and Hg(II), which serves as a signal amplification tag in a multiplex electrochemical sensing platform.