Omics · study · 2026
Immunomodulation of the prostate tumor microenvironment following inorganic Arsenic exposure
Listed in NCBI GEO
The tumor microenvironment shapes how prostate cancer (PCa) progresses through stromal-immune interactions.
Description
We investigated how adipose-derived mesenchymal/stromal cells (ASC) and chronic inorganic arsenic (iAs) exposure jointly influence PCa by using a Ras-driven murine model. ASC-conditioned media enhanced TC2Ras viability, while iAs reversed this effect.
In vivo, ASC+iAs tumors showed increased weight, altered immune infiltration, and transcriptomic remodeling, including a sustained IFN-IRF1 axis and immune checkpoint upregulation. ASC-iAs crosstalk promotes immune tolerance, revealing mechanisms by which environmental toxicants modulate cancer immunity.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE317nnn/GSE317208 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE317208 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1406262 ncbi.nlm.nih.gov/bioproject/PRJNA1406262 ↗
project · from NCBI GEO
- PubMed 41730271 pubmed.ncbi.nlm.nih.gov/41730271 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE317208 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |