Omics · study · 2026
RNA-seq analysis of tumors derived from a xenograft model treated with the KDM5B inhibitors JB-157 or JB-161.
Listed in NCBI GEO
KDM5B, a member of the KDM5 family of histone demethylases, functions as a key epigenetic regulator by removing di- and trimethyl groups from H3K4 (H3K4me2/3), thereby promoting transcriptional repression.
Description
It is involved in fundamental biological processes, including development, stem cell maintenance, and tumorigenesis, and its dysregulation has been associated with multiple cancer types. Given its critical role in cancer biology, KDM5B has emerged as an attractive target for therapeutic intervention.
Therefore, we conducted a screening campaign to identify novel KDM5B inhibitors. In this study, we investigated whether the KDM5B inhibitors JB-157 and JB-161, identified through our screening, exert antitumor effects.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE319nnn/GSE319664 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319664 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1424927 ncbi.nlm.nih.gov/bioproject/PRJNA1424927 ↗
project · from NCBI GEO
- PubMed 42324589 pubmed.ncbi.nlm.nih.gov/42324589 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE319664 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |