Excel · study · 2026
Targeting Ewing sarcoma by ex vivo expanded IL1RAP CAR modified TGFbeta imprinted NK cells in combination with IL-15 agonist and anti-GD2 antibody
Listed in NCBI GEO
The prognosis of patients with metastatic Ewing sarcoma (ES) is dismal, largely due to therapy resistance within the tumor microenvironment (TME).
Description
Here, we aim to overcome ES TME resistance to natural killer (NK) cells by a combinatorial immunotherapy approach that enables NK tumor-specific-targeting via chimeric antigen receptor (CAR) against interleukin-1 receptor accessory protein (IL1RAP), circumvents transforming growth factor beta (TGFβ)-mediated immunosuppression by TGFβ-imprinting of NK cells, increases NK cell antibody dependent cellular cytotoxicity (ADCC) via an anti-GD2 antibody dinutuximab, and improves NK cell persistence and ADCC by an IL-15 agonist NKTR-255.
Single-cell-RNAseq analyses of cells from xenograft tumors were performed to identify mechanisms of response/resistance to this combinatorial immunotherapy.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE310nnn/GSE310801 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE310801 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1367096 ncbi.nlm.nih.gov/bioproject/PRJNA1367096 ↗
project · from NCBI GEO
- PubMed 42398968 pubmed.ncbi.nlm.nih.gov/42398968 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE310801 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |