Omics · study · 2026
Effect of genetic background and limb immobilization on tibial metaphysis transcriptomes in 19‑week male mice
Listed in NCBI GEO
This study profiles tibial metaphysis RNA expression across eight inbred mouse strains subjected to unilateral hindlimb immobilization.
Description
RNA‑seq was performed on metaphyseal tissue from immobilized and contralateral control limbs to identify strain‑specific transcriptional responses to mechanical unloading. Differential expression analysis revealed distinct genetic‑background–dependent signatures associated with bone remodeling, inflammation, and mechanotransduction pathways.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE331nnn/GSE331381 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE331381 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1467987 ncbi.nlm.nih.gov/bioproject/PRJNA1467987 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE331381 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |