Association between triglyceride glucose index and depression in polycystic ovary syndrome

After adjustment by Infertility, acne, hirsutism, age, BMI, education, and annual family income, there was still a significant positive correlation[OR= 3.965(95% CI:2.692~5.840), P= 0.000]. Model 3 (a fully adjusted model) had approximately a 4-fold increase in odds of depression risk per unit elevation in the TyG index [3.884 (2.501~6.031)]. The area under the ROC curve (AUC) of the predictive model for depression with TyG index was 0.687(95% confidence interval, 0.644~0.730), with sensitivity equal to 61.5% and specificity equal to 66.8%.

After adding other predictive factors to the TyG index, the AUC improved to 0.730(95% confidence interval, 0.69~0.77), with sensitivity equal to 63.8% and specificity equal to 70.7%.Conclusions: A high TyG index was associated with a higher odds of having depression in PCOS, after adjustment for potential confounders. This indicated that the TyG index may have been an independent predictor of depression development.