Supplementary file 1_Free triiodothyronine in intracranial aneurysms: a sex-specific association with unruptured disease and a non-thyroidal illness signal after rupture.docx

Materials and.</p>Methods<p>This is a retrospective single-centre case–control study of patients with unruptured (UIA) or ruptured intracranial aneurysms (RIA) and aneurysm-free controls. Low free triiodothyronine (fT3) was defined as below 3.5 pmol/L. Multivariable logistic regression was adjusted for age, sex, hypertension, alcohol abuse, and smoking.</p>Results<p>The cohort comprised 1,100 patients (60.0% female), including UIA (n = 213), RIA (n = 629), and controls (CTRL, n = 258).

Low fT3 was observed in 58.8% of RIA patients (p < 0.001). In multivariable logistic regression analysis including age, sex, hypertension, alcohol abuse, and smoking, female sex (OR 4.90; 95% CI 2.70–8.92) and low fT3 (OR 3.05; 95% CI 1.28–7.28) were independently associated with UIA. Low fT3 was less frequent in UIA (3.8%) than in CTRL (14.0%) but was independently associated with UIA after risk-factor adjustment.