Data · dataset · 2025
Elevated prevalence of 21-hydroxylase antibody in individuals with type 1 diabetes mellitus: A meta-analysis
Listed in ScienceDB
Objective Type 1 diabetes mellitus (T1DM) is a chronic disorder resulting from the autoimmune destruction of pancreatic β-cells, frequently accompanied by derangements in immune regulation.
Description
The 21-hydroxylase antibody, a specific autoantibody targeting adrenal tissue, has been widely recognized as a pivotal immunological marker for Addison's disease. Considering that the autoimmune mechanism might serve as a shared pathological foundation for both 21-hydroxylase antibody positivity and T1DM, co-occurrence of these two conditions may be observed in certain patients.
This meta-analysis aims to provide more robust and statistically valid evidence by integrating the raw data from relevant studies, thereby clarifying whether a statistical association exists between 21-hydroxylase antibody positivity and T1DM.
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Methods
A systematic search was conducted across the PubMed, Web of Science, CNKI, and CBM databases. Based on the data extracted from the retrieved studies, the odds ratio (OR) and its 95% confidence interval (CI) were calculated to assess the statistical association between the two variables.Results A total of 10 independent studies were included in this investigation, encompassing 2 852 patients with T1DM and 1 596 non-diabetic control subjects.
The results of the meta-analysis indicated that the prevalence of positive 21-hydroxylase antibody among T1DM patients was significantly higher than that in the control group [OR=3.35, 95%CI(1.80, 6.24)]. Sub-group analyses revealed that, within both the Asian and American populations, the proportion of T1DM patients with positive 21-hydroxylase antibody was notably higher compared to the control groups [OR=2.99, 95%CI(1.17, 7.66); OR=8.79, 95%CI(2.04, 37.98)].
Conversely, no statistically significant association was detected in the European population [OR=1.17, 95%CI(0.36, 3.79)]. The results of sensitivity analyses and publication bias assessments affirmed the sound stability and reliability of the conclusions drawn from this meta-analysis.Conclusion The results of this meta-analysis demonstrate that the prevalence of positive 21-hydroxylase antibody is significantly elevated in patients with T1DM compared to non-diabetic controls, suggesting a potential specific immunological connection between the two entities.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.j00217.09634 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
- Inferred from text
- Disease 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.j00217.09634 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:disease | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license_text | source · scidb cn | connector:scidb_cn@1.0.0 | |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |