Omics · study · 2026
Synergistic blockade of cyclophilin A and pathogenic immunity minimizes pregnancy-context pathologies in response to the Zika virus
Listed in NCBI GEO
Zika virus (ZIKV) jeopardizes fetal health through both vertical transmission and placental disorders, while the regulatory mechanisms and therapeutic opportunities remain elusive.
Description
Here, we reveal cyclophilin A (CypA) as a critical host factor necessary for placental ZIKV replication, functioning independently of its isomerase activity and calcineurin-dependent pathway.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE308nnn/GSE308795 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE308795 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1332729 ncbi.nlm.nih.gov/bioproject/PRJNA1332729 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE308795 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |