Imaging · study · 2026
C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain.
Listed in NCBI GEO
C1q, the initiator of the classical complement cascade, mediates synaptic elimination during development and disease, yet the triggers for C1q deposition on synapses in the adult brain remain unclear.
Description
Using in vivo chemogenetics, we demonstrate that neuronal hyperactivity acts as a trigger for region-specific C1q deposition and synapse loss in the adult hippocampus of wild-type mice; importantly, C1qa deficiency abolishes this activity-dependent synapse remodeling.
Conversely, suppressing perforant pathway hyperactivity in a mouse model of Alzheimer’s disease lowers local Aβ levels, reduces C1q deposition, and partially rescues synapse loss. Further, using spatial transcriptomics, live cell tracking, super-resolution microscopy and other molecular and cellular tools, we report a surprising role for B lymphocyte lineage antibody-secreting cells in the activity-dependent C1q deposition and synapse loss in the non-diseased adult hippocampus.
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Overall, our work suggests a functional link between neuronal hyperactivity and C1q-mediated synapse loss in the adult brain and introduces immunoglobulins as players in this process.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327095 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327095 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1449445 ncbi.nlm.nih.gov/bioproject/PRJNA1449445 ↗
project · from NCBI GEO
- PubMed 42424464 pubmed.ncbi.nlm.nih.gov/42424464 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Mus musculus · Other
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · Microscopy 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE327095 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:microscopy | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |