Supplementary file 1_Evaluation of umbilical cord blood presepsin in the diagnosis of neonatal early-onset sepsis.docx

These biomarkers were compared to assess presepsin's diagnostic performance relative to traditional inflammatory markers for neonatal EOS.</p>Results<p>The study included 195 eligible neonates. Umbilical cord presepsin levels were significantly elevated in the EOS group compared to controls (1,084.51 pg/mL vs. 618.94 pg/mL, p < 0.001). Presepsin demonstrated higher diagnostic accuracy than traditional biomarkers (white blood cell (WBC), CRP, PCT, and IL-6) for EOS detection.

Based on our analysis, the maximum Youden index was 0.726, corresponding to an optimal cutoff value of 800.91 pg/mL for umbilical cord blood presepsin in predicting neonatal EOS, with a sensitivity of 88.0%, specificity of 84.6%, and the area under the curve (AUC) of 0.941.</p>Conclusion<p>Umbilical cord presepsin showed higher diagnostic accuracy than traditional inflammatory markers for neonatal EOS. and the optimal cut-off value of umbilical-blood presepsin to predict EOS was 800.91 pg/mL.</p><p>Clinical Trial Registration: chictr.org.cn/showproj.aspx?proj=194627, identifier ChiCTR2300072525.</p>