Omics · study · 2026
Identification of progenitor cells that drive Interleukin 11-dependent tumor-stroma coevolution in advanced melanoma [Full_Low_Serum]
Listed in NCBI GEO
Tumor mesenchymal stem cells (TMSCs) orchestrate tumor microenvironment (TME) transformation via their ability to transdifferentiate.
Description
Metastatic solid tumors often feature neural crest-like/mesenchymal phenotypes characterized by high expression levels of TGFβ-dependent epithelial-to-mesenchymal transition (EMT) and EMT-like programs. Specifically, EMT-like endothelial-to-mesenchymal (EndMT) programs are responsible for the differentiation of TMSCs towards cancer-associated fibroblasts (CAFs).
CAFs dictate tumor progression, invasiveness, and immune evasion. Exploring the molecular determinants of CAFs generation and pathobiology is thus of paramount importance to improve therapy response. The in vitro responses of patient-derived TMSCs were investigated upon recapitulating TGFβ-driven EMT-like TME traits.
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The resulting myofibroblastic CAFs (myCAFs) originated from TMSCs via EndMT were characterized by enhanced Interleukin-11 (IL11) expression and secretion. We propose IL11+ myCAFs as a driver of the tumor-stromal crosstalk responsible for the pro-tumorigenic, mesenchymal, angiogenic, and immunosuppressive TME transformation in metastatic melanoma.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE338nnn/GSE338553 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE338553 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1495144 ncbi.nlm.nih.gov/bioproject/PRJNA1495144 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE338553 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |