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Omics · study · 2026

scRNA-seq assessment of the impact of loss of Tgfbr2 in DPT-expessing fibroblasts in a model of fibrotic lung disease

Listed in NCBI GEO

To investigate the cell intrinsic role of Tgfbr2 signaling in fibroblasts in response to a fibrosis inducing lung injury, we crossed Tgfbr2.flox mice to Dpt.CreERT2 mice.

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We then perfomed gene expression profiling using scRNA-seq in conditional Tgfbr2 ko and wt controls at day 24 post bleomycin injury.

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Expression profiling by high throughput sequencing · Mus musculus · Other
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Life Sciences
Inferred from text
Disease 75% · Single-cell RNA sequencing 65%
Provenance · 1 source records, 10 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE29691814 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[disease].local:disease:diseaseenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[method].geo_series_type:othersource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[modality].local:modality:single-cell-rna-seqenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (65%)
concepts[organism].NCBITaxon:10090source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title