Data · dataset · 2025
mRNA expression profile in DLD-1 and MOLT-4 cancer cell lines cultured under Microgravity
Listed in NASA Data Portal
DLD-1 and MOLT-4 cell lines were cultured in a rotating cell culture system to simulate microgravity and mRNA expression profile in comparison to Static controls.
Description
Cells were grown in 10mL rotating vessels in a Rotary Cell Culture System (RCCS) and in 60mm Petri dishes (test control respectively). Two replicates of test (Microgravity) and control (static) each from DLD-1 and MOLT-4 were analyzed by microarray.
Simulated microgravity affected the solid tumor cell line DLD-1 markedly which showed a higher percentage of dysregulated genes compared to the hematological tumor cell line MOLT-4. Microgravity affects the cell cycle of DLD-1 cells and disturbs expression of cell cycle regulatory gene networks. Multiple microRNA host genes were dysregulated and significantly mir-22 tumor suppressor microRNA is highly upregulated in DLD-1.
Links
Get the data
- genelab-data.ndc.nasa.gov /genelab/accession/GLDS-125 ↗
mRNA expression profile in DLD-1 and MOLT-4 cancer cell lines cultured under Microgravity
download · from data nasa gov
Where it is published
- NASA Data Portal dataset page data.nasa.gov/dataset/mrna-expression-profile-in-dld-1-and-molt-4-cancer-cel… ↗
landing page · from data nasa gov
Catalogue records · 1
- CKAN API data.nasa.gov/api/3/action/package_show?id=ef0a2083-1f28-4452-8884-93c503d80… ↗
metadata API · from data nasa gov
Topics
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Related
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NASA Data Portal | ef0a2083-1f28-4452-8884-93c503d80d6b | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:cancer | enrichment · data nasa gov | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| created_date | source · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| description | source · data nasa gov | connector:data_nasa_gov@1.0.0 | /notes |
| license_text | source · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| publication_date | source · data nasa gov | connector:data_nasa_gov@1.0.0 | |
| title | source · data nasa gov | connector:data_nasa_gov@1.0.0 | /title |
| updated_date | source · data nasa gov | connector:data_nasa_gov@1.0.0 |