Hesperidin alleviates chronic atrophic gastritis in rats by modulating the NRF2/SLC7A11/GPX4 signaling pathway to inhibit ferroptosis

Sixty rats were divided into six groups for intervention experiments, and ELISA, HE staining, TUNEL staining, and Western blot techniques were used to detect inflammatory factors, gastrointestinal hormones, oxidative stress indicators, iron ion levels, cell apoptosis, and expression of key pathway proteins.

The results confirmed that the CAG model rats exhibited inflammatory disorders, gastrointestinal hormone imbalances, increased oxidative stress, activation of iron death, and gastric mucosal damage; Hesperidin and iron death inhibitors can effectively reverse the pathological abnormalities mentioned above, while NRF2 inhibitors can counteract the protective effect of hesperidin. The dataset includes a summary of experimental data, WB raw band images, HE staining images, TUNEL staining images, etc.