Cranial CT Registration & Quality Evaluation Software

General InformationResource Type: Software Application / Analytic Tool & Associated Test DataTitle: HeadAligner Web Pro v2.0 - Automated Cranial CT Spatial Alignment and Multicenter Quality Control SuiteDeveloper Affiliation: Nanjing Medical University Fourth Affiliated HospitalContact: blasthao@hotmail.com2. DescriptionThe Cranial CT Registration & Quality Evaluation Software V1.0 is an open-source, Python-based application deployed via Streamlit.

It is engineered to resolve spatial heterogeneity in multi-center cranial CT datasets. This toolkit automates the rigid alignment of cranial CT scans to a standardized geometric space while simultaneously performing rigorous quantitative image quality control.3. Core Capabilities & MethodologyThe software encapsulates the following workflows:Automated Rigid Registration: Utilizes `SimpleITK` with Mattes Mutual Information and Regular Step Gradient Descent optimization to align moving CT scans to a standard template space.Quantitative Quality Assessment (QA): Automatically segments brain tissue masks to compute essential QA metrics, including Signal-to-Noise Ratio (SNR), Contrast-to-Noise Ratio (CNR), Centroid Shift (mm), Symmetry Index, and 3D Euler Angles (Pitch, Roll, Yaw).Statistical Verification Pipeline: Includes built-in normality testing (Shapiro-Wilk) and paired statistical tests (t-test / Wilcoxon signed-rank) to evaluate the pre- and post-alignment image quality across patient cohorts.Clinical Network Integration (PACS): Features native `pynetdicom` integration allowing processed DICOM series with newly generated, compliant UID metadata to be seamlessly archived (C-STORE) back to hospital PACS environments.4.