Data from Medullary and C3-C4 Propriospinal Pathways

Data related to pnas article entitled "Medullary and C3-C4 Propriospinal Pathways Underlying Mammalian Forelimb Movement Control" Jindal et al. Our study identifies a conserved medullary network, comprising the Lat-RM and CauM, underlying forelimb movement control across species, while also revealing cortical differences potentially driven by task demands or inter-species neuroanatomical variations. This network follows an orderly organization of cortical connections along the ventro-medio-dorsal axis of the medulla.

We provide the first functional mapping of the human C3–C4 propriospinal pathway, which exhibits anatomically segregated connectivity with brainstem nuclei, cerebellum, and motor cortex. Together, our findings suggest an indirect motor pathway involving both the reticulospinal tract and the C3–C4 propriospinal system that contributes to fine hand motor control, and highlight the central role of the propriospinal system in integrating reticular, cortical, and cerebellar inputs to support this function.