Excel · study · 2026
Piezo1 Modulates Hematopoietic Homeostasis and Chronic Myelomonocytic Leukemia Progression [low-put RNA-seq]
Listed in NCBI GEO
We demonstrated that PIEZO1 is essential for sustaining hematopoietic homeostasis.
Description
To elucidate the underlying mechanism of Piezo1 in normal hematopoiesis, we analyzed and compared the gene expression profiles of hematopoietic stem cells (HSCs) — which were isolated via flow cytometry from Piezo1 floxed/floxed; Vav-iCre mice and control mice. Our findings revealed that, among the differentially expressed genes (DEGs) in Piezo1 conditional knockout (cKO) HSCs, the cell adhesion pathway was significantly enriched and exhibited downregulation.
This downregulation of the cell adhesion pathway was associated with reduced expression of integrin beta1.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313739 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313739 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1381508 ncbi.nlm.nih.gov/bioproject/PRJNA1381508 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE313739 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |