Data · dataset · 2024
Alginate Oligosaccharides Improve Glycolipid Metabolism Disorder
Listed in ScienceDB
Diabetes, fatty liver, and other disorder of glycolipid diseases threaten human health.
Description
Alginate oligosaccharides (AOS) are derived from brown alga by alginate degradation. AOS has many biological activities and is easier to be absorbed.
In the present study, the potential beneficial effects of AOS on improving the disorder of glycolipid metabolism by regulating gut microflora was investigated. The results show that AOS improves type 2 diabetes (T2DM) by reducing blood glucose, total cholesterol, and total triglycerides and regulating the expression of PEPCK, G6Pase, HMGCR, CYP7A1, LDLR, SMYD3, SREBP-2 in high-fat-diet-induced mice, and regulates the expression of SREBP-2, HMGCR, and SMYD3 in oleic acid-induced HepG2.
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Besides, AOS adjusts the abundance of gut microflora in T2DM mice and improves the production of short-chain fatty acids (SCFAs) at the same time. Furthermore, AOS can be efficiently degraded and utilized by the gut microflora of nonalcoholic fatty liver (NAFLD) patients faces while regulating the production of SCFAs and effectively promoting the proliferation of intestinal lactobacillus. To our best knowledge, this study is the first to illustrate that AOS improves glycolipid metabolism disorder by regulating intestinal microflora in both animal model and clinical patient feces.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.16045 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
- Inferred from text
- Biochemistry and cell biology 70%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.16045 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].anzsrc:group:3101 | enrichment · scidb cn | taxonomy-embedding@1.0.0 | title+keywords+description (70%) |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license_text | source · scidb cn | connector:scidb_cn@1.0.0 | |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |