Omics · study · 2026
Transcriptomic effects of intermittent parathyroid hormone treatment on Sox9-lineage osteoprogenitors
Listed in NCBI GEO
We employed 10X Genomics single cell RNA-sequencing to study the bone anabolic effects of intermittent parathyroid hormone treatment (iPTH) on growth-associated progenitors.
Description
These osteoblast progenitors, marked by the expression of the transcription factor SRY-box transcription factor 9 (Sox9), reside in the growth plate and perichondrium that respond to iPTH in early postnatal mice. Whether these cells respond in adult mice is unknown.
Using lineage tracing approach with Sox9-CreERT2 crossed with Ai9 tdTomato reporter mice, we traced Sox9-expressing cells and their descendants following 10 days of vehicle or iPTH treatment. This study represents a single cell atlas of Sox9-lineage cells following 10 days of iPTH treatment.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326229 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326229 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1444175 ncbi.nlm.nih.gov/bioproject/PRJNA1444175 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE326229 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |