Pediococcus acidilactici derived from feline milk alleviates the inflammatory response in bacterial enteritis by activating the TLR4/NF-κB signaling pathway

Methods

Lactobacilli were isolated from cat milk to obtain cat milk-derived probiotic YH-15 for enumeration. E. coli ATCC25922 was used to establish a mouse enteritis model 50 Balb/c mice were randomly divided into 5 groups, which were the control group (CONTROL), the Escherichia coli group (E. coli), the YH-15 107+ E. coli prevention group, the YH-15 108+ E. coli prevention group and the YH-15 109+ E. coli prevention group, and pathological tissue observation was carried out using Hematoxylin-Eosin staining (HE staining) to analyze the jejunal structure, villus length, and crypt depth.