Figure 2 from Circadian Genotypes in <i>PER3</i> and Time of Prostate Cancer Radiotherapy Interact to Affect Risk of Late Side Effects

<p><b>A,</b> Predicted probability (<i>y</i>-axis) of a patient developing late RB (top row) and late UI (second row) as derived from fixed-effects regression models for different treatment times (solar time of day, <i>x</i>-axis) and genotype for <i>VAMP3</i> SNP rs11121022 and adjacent <i>PER3</i> SNP rs172933, rs696305, rs35128310, rs488728, rs288640, and rs697689. Probabilities of developing each late side effect are given for patient groups grouped by genotype at each SNP.

Possible patient genotypes are colored as follows: purple, homozygous for allele 1; green, heterozygous; yellow, homozygous for allele 2. Alleles are arbitrarily assigned as allele 1 or allele 2, and their assignments can be determined from <b>B</b>. Shaded areas show 95% CI for predictions. <b>B,</b> Proportion of patients in the study cohort (European population) with given genotypes for each SNP.