An Injectable Hf-Alendronate Supramolecular Condensate Enables Radioimmunotherapy for Osteosarcoma via COX-2/PGE2 Inhibition and Systemic Immune Activation

However, its therapeutic effectiveness is frequently constrained by inadequate radiosensitization and an immunosuppressive tumor microenvironment, which hinders systemic antitumor immune responses and facilitates tumor recurrence and metastasis. In this study, We designed an injectable supermolecular complex of alendronate (Hf-ALN) containing the COX-2 inhibitor celecoxib (CXB), and combined it with radiotherapy to treat osteosarcoma in Balb/c mice.

Subsequently, transcriptome analysis was conducted.This injectable radiological immunomodulatory aggregate represents a promising approach that integrates local radiosensitization with immune microenvironment reprogramming to enhance the efficacy of postoperative radiotherapy for osteosarcoma.