Omics · study · 2026
Brain corticogenesis promotes SARS-CoV-2 neuro-glial tropism through lipid-dependent viral replication
Listed in NCBI GEO
Human induced pluripotent stem cell (hIPSC)-derived cerebral organoids (CBOs) provide a potential in-vitro model to study cellular composition and transcriptional dynamics during human brain development.
Description
This single-cell RNA analysis aims to evaluate the capacity of CBOs to reflect key brain developmental stages, assess their transcriptional fidelity against human fetal brain references, and characterize lipid metabolic gene programs associated with brain maturation, collectively providing a transcriptomic framework for understanding coordinated molecular and cellular changes during human brain development.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE334nnn/GSE334412 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334412 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1474980 ncbi.nlm.nih.gov/bioproject/PRJNA1474980 ↗
project · from NCBI GEO
- PubMed 42492515 pubmed.ncbi.nlm.nih.gov/42492515 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE334412 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |