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Omics · study · 2026

Gene expression profiling of 22Rv1 cells treated with a CDK9 degrader, Compound 45 (D45)

Listed in NCBI GEO

As one of the serine/threonine protein kinase family members, Cyclin-dependent kinase 9 (CDK9) functions as a critical regulator of transcription.

Description

Its overexpression has been observed in various cancers, including prostate cancer, positioning it as a potential therapeutic target. D45, a newly developed small molecular CDK9 degrader, has been shown to significantly inhibit the growth of triple-negative breast cancer cells.

Currently, we carried out a study to explore the role of CDK9 in castration-resistant prostate cancer (CRPC). Hence, human CRPC 22Rv1 cells were treated with small molecule compound, D45, targeting CDK9, followed by RNA-sequencing.

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Expression profiling by high throughput sequencing · Homo sapiens
From keywords
Life Sciences
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Cancer 75%
Provenance · 1 source records, 8 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE28803114 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[disease].local:disease:cancerenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[organism].NCBITaxon:9606source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title