Dataset:<b>Coronary Artery Lesions in Pediatric Scrub Typhus from Guangzhou</b>

Although it typically causes fever, rash, and multi-organ dysfunction, its capacity to damage coronary arteries in children — a complication most commonly associated with Kawasaki disease — has rarely been reported. In this study, we analyzed seven children treated at a major pediatric center in Guangzhou, China, who developed coronary artery aneurysms, dilatation, or intimal thickening following Orientia tsutsugamushi infection.

Three of these children also met criteria for Kawasaki disease yet continued to have high fevers after standard immunoglobulin treatment, only improving once antibiotics targeting the bacterium were started. All patients eventually recovered, and coronary artery abnormalities normalized in those with follow-up imaging. Our findings highlight that scrub typhus should be considered as a potential cause of coronary artery lesions in children, especially in endemic regions, and emphasize the importance of early microbiological diagnosis and specific antimicrobial therapy.</p>