Data · dataset · 2026
<p>Experimental data gathered during prolonged osmotic challenge and recovery.</p>
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.1371/journal.pcbi.1014832.g001
Description
<p>The data here (available in supporting material <a href="ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014832#pcbi.1014832.s002" target="_blank">S1 Data</a>) is gathered from multiple published sources where rats have been measured during a prolonged osmotic challenge consisting of several days of dehydration (circles) or salt loading (squares), and the following recovery period, with normal water access restored.
During the challenge osmolarity and plasma [Na<sup>+</sup>] (top panels) rise mostly linearly, with some data showing a reduced rate of rise and plateau towards day 4 and 5. Radioimmunoassay measured plasma vasopressin concentration (mid left) mostly shows a matching linear rise, but data is mostly limited to three days, and varies in magnitude between dehydration (higher) and salt loading (lower) protocols. Vasopressin cell body mRNA content (mid right) shows a mostly linear rise after one day that eventually plateaus.
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The data is variable, but the most consistent experiments, with more time points, suggest a five to eight fold rise in content. The core target data for the model is the measurements of pituitary store content (bottom). During the challenge there is a mostly linear fall in pituitary content, which slows after day 3, falling to around 15–30% of normal content.
During recovery, where osmolarity rapidly (a few hours) returns to normal, the stores are slowly replenished over about two weeks. The faster recovery shown here (blue squares) is in rats made hypo-osmotic after the prolonged hyper-osmotic challenge. Detail on the sources (different colours) is given in <a href="ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014832#pcbi.1014832.s001" target="_blank">S1 Fig</a>.</p>
Links
Where it is published
- DOI doi.org/10.1371/journal.pcbi.1014832.g001 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Biochemistry and cell biology · Biochemistry and cell biology · Biochemistry and cell biology · Chemistry · Chemistry · Chemistry · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Life Sciences · Life Sciences · Life Sciences · Medicine & Health · Medicine & Health · Medicine & Health · Physics · Physics · Physics · Research, science and technology policy · Research, science and technology policy · Research, science and technology policy
Provenance · 3 source records, 26 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34035992 | 13 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/34035992 | 13 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/34035992 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].anzsrc:field:440710 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Science Policy'] |
| concepts[field].anzsrc:field:440710 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Science Policy'] |
| concepts[field].anzsrc:field:440710 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Science Policy'] |
| concepts[field].anzsrc:group:3101 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].anzsrc:group:3101 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].anzsrc:group:3101 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].local:field:chemistry | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:physics | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:physics | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:physics | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |