Transcriptome analysis of mouse lungs following environmentally relevant low-dose PFOS exposure in mice

To explore the molecular effects of environmentally relevant PFOS exposure, we examined lung transcriptional responses following chronic low-dose exposure in mice. Transcriptomic analysis revealed a set of differentially expressed genes in PFOS-exposed lungs.

Functional enrichment indicated that these genes were primarily associated with immune-related processes, including immune system activity, immunoglobulin complexes, and chemokine or immunoglobulin receptor interactions. These findings suggest that low-dose PFOS exposure may influence early immune-related molecular pathways in the lung.