Data · dataset · 2026
QUB-1985: a bioactive peptide from the frog skin secretion of Odorrana livida
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32863022.v1
Considering the severe problem of drug resistance developed by multiple pathogenic microorganisms, scientists have been working on developing novel therapeutic agents to replace conventional antibiotics.
Description
Antimicrobial peptides (AMPs), possessing broad-spectrum antimicrobial activity, have raised great interests among medical field for its potential bioactivity against bacteria, fungi, viruses and cancer cells and its multi-target mechanisms. <br><br>In this study, a cDNA encoding an AMP precursor was isolated and identified from the skin secretion of the wild green mountain frog, Odorrana livida, with the assistance of shotgun cloning.
The obtained mature peptide consists of 21 amino acid residues, GLLSGILGVGKKIVCGLSGLC, and this peptide was named QUB-1985 according to its molecular mass. Afterwards, adequate peptides were acquired through SPPS, and several assays were carried out on QUB-1985 to determine its biological activities. <br><br>In antimicrobial assay, QUB-1985 exhibited potent antimicrobial activity against three model microorganisms, which are Staphylococcus aureus (Gram-positive bacteria), Escherichia coli (Gram-negative bacteria) and Candida albicans (fungi), and the MICs are 4, 8 and 16 μM respectively.
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Meanwhile, the cytotoxicity of QUB-1985 on horse red blood cells was rather low with a haemolysis of about 30% at the concentration up to 256 μM, which is more than 16-fold of the MICs against the three model microorganisms. In anticancer assay, however, no obvious anticancer activity was observed in QUB-1985 in this study.<br>
Links
Where it is published
- DOI doi.org/10.17034/32863022.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science
- Inferred from text
- Cancer 75%
Provenance · 3 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32863022 | 13 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32863022 | 13 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32863022 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:cancer | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |