Filifactor alocis FtxA-dependent suppression of inflammation and apoptosis

For this, we have used the ftxA-expressing strain, ATCC 35896, and F. alocis 148B-17U, which naturally lacks the gene encoding FtxA. Using RNA-Seq and cytokine array analysis we have pinpointed a role of FtxA in shifting the host response towards immunosuppression, also inhibiting apoptosis, immune cell recruitment, and with a potential role as well in downregulating mitochondrial and oxidative phosphorylation pathways in the THP-1 cells.

Such role(s) in immune suppression could provide a plausible explanation why FtxA is associated with the progress and severity of periodontal disease, and further studies on mechanistic interactions between FtxA and host cells might therefore reveal novel potential therapeutic targets.