Excel · study · 2026
Cell quality attributes, clinical features and biomarker levels influence osteoarthritis patient responses to mesenchymal stromal cells
Listed in NCBI GEO
Bone marrow-derived mesenchymal stromal cells (MSC(M)) are promising immunomodulatory therapeutics for osteoarthritis (OA); however, mixed clinical efficacy has been reported.
Description
We present new 24-month follow-up data from our previous clinical trial investigating single intra-articular injection of autologous MSC(M) in knee OA, with analysis of responders and non-responders to probe differential baseline disease features and MSC(M) basal fitness.
Analysis of patient-reported outcome measures (PROMs) showed responders had greater OA severity at baseline. Lower baseline levels of angiogenic/inflammatory synovial fluid biomarkers correlated to improved PROMs. A gene panel of putative immunomodulatory critical quality attributes (CQAs) distinguished MSC(M) donors classified as responders versus non-responders.
Read the rest (1 more)
Furthermore, an algorithm was developed to rank MSC(M) donors based on in vitro monocyte/macrophage polarization readouts and clinical efficacy. Lastly, microRNA-sequencing of MSC(M) revealed 69 microRNAs associated with responder status. Our data provide evidence for specific clinical phenotype features and biomarkers to stratify OA patients, as well as CQAs for quantifying basal immunomodulatory fitness of MSC(M) in knee OA.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE249nnn/GSE249452 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE249452 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1049065 ncbi.nlm.nih.gov/bioproject/PRJNA1049065 ↗
project · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Non-coding RNA profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE249452 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:non-coding-rna-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |