Omics · study · 2026
Transcriptomic profiling of HepG2 cells upon EZH2 knockdown
Listed in NCBI GEO
This RNA-seq dataset was generated to investigate transcriptomic changes resulting from EZH2 knockdown in the human hepatocellular carcinoma cell line HepG2.
Description
Cells were treated with either control (untreated or si-NC) or si-EZH2. Differential gene expression analysis identified genes regulated by EZH2 depletion, enabling the characterization of EZH2-dependent transcriptional programs in HCC cells.
This dataset provides a resource for studying the functional impact of EZH2 on hepatocellular carcinoma transcriptome and for validation of EZH2-targeted therapeutic strategies.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE312nnn/GSE312184 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE312184 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1372615 ncbi.nlm.nih.gov/bioproject/PRJNA1372615 ↗
project · from NCBI GEO
- PubMed 41622630 pubmed.ncbi.nlm.nih.gov/41622630 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE312184 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |