Raster · study · 2026
Spatially Resolved Cell-Cell Communication in Small Cell Lung Cancer Reveals Macrophage-Driven Immune Evasion Programs
Listed in NCBI GEO
Small cell lung cancer (SCLC) exhibits poor responses to immunotherapy despite abundant immune infiltration.
Description
We performed single-cell spatial transcriptomic profiling of more than 2.5 million cells from six surgically resected limited-stage SCLC tumors using the 10x Genomics Xenium In Situ platform (5K Human Pan Tissue & Pathways Panel). Spatially resolved cell-cell communication analysis identified macrophages as the dominant communicating immune population and revealed distinct spatial macrophage states associated with differential T-cell phenotypes and immune evasion programs.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE343nnn/GSE343063 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE343063 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1510205 ncbi.nlm.nih.gov/bioproject/PRJNA1510205 ↗
project · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Other
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE343063 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |