Omics · study · 2026
Sturgeon Cartilage–Derived Peptides Promote Cartilage Repair-Associated Responses in Osteoarthritis via Integrin αvβ3–PI3K/Akt Signaling
Listed in NCBI GEO
Osteoarthritis (OA) features progressive cartilage loss with no effective regenerative therapies.
Description
This study investigated sturgeon cartilage peptides (SCPs) for OA repair and identified key bioactive peptides and mechanisms. SCPs, prepared by trypsin hydrolysis, were evaluated in in vitro and in vivo OA models.
SCPs markedly improved cartilage damage, reduced matrix degradation, and increased chondrocyte proliferation to 126%.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE338nnn/GSE338020 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE338020 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1492117 ncbi.nlm.nih.gov/bioproject/PRJNA1492117 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE338020 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |