Pasteurized Akkermansia muciniphila ameliorates preeclampsia via inhibiting mitochondrial dysfunction-mediated placental apoptosis in vivo and in vitro

Emerging evidence suggests that pasteurised Akkermansia muciniphila (pAKK) is a promising candidate for preventing or treating obesity-related metabolic disorders. Nonetheless, the modulatory function and underlying mechanisms of pAKK as a supplement for PE have yet to be investigated.

In this study, we examined the impact of pAKK oral administration on PE and its underlying mechanisms. Our findings demonstrate that pAKK significantly improved PE-like symptoms in mice induced by nitro-L-arginine methylester (L-NAME) in a dose-dependent manner. Importantly, pAKK inhibited L-NAME-induced placental apoptosis, countered apoptosis-related biochemical alterations like the increase in the Bax/Bcl-2 ratio, and the activation of cleaved-Caspase-3, alongside mitigating L-NAME-induced placental mitochondrial dysfunction.