Data · dataset · 2026
<p>Functional enrichment analysis links FABP5 to immune activation and NF-κB signaling pathways.</p>
Listed in ZivaHub
<p>(A) Heatmap of DEGs between high and low FABP5 expression groups.
Description
(B) Gene Ontology (GO) enrichment analysis of DEGs, showing significant biological processes (BP), cellular components (CC), and molecular functions (MF) related to immune regulation. (C) KEGG pathway enrichment analysis highlighting immune-related pathways associated with FABP5 expression, such as cytokine–cytokine receptor interaction, chemokine signaling, Th1/Th2 and Th17 cell differentiation, B cell receptor signaling, NF-κB signaling, PI3K–Akt signaling, T cell receptor signaling, IL-17 signaling, and JAK–STAT signaling.
(D) Correlation analysis revealed a positive association between FABP5 expression and cancer inflammatory gene signatures. (E) Heatmap showing co-upregulation of NF-κB pathway genes (NF-κB1, NF-κB2, RELA) in FABP5-high tumors.</p>
Links
Where it is published
- DOI doi.org/10.1371/journal.pone.0356359.g007 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Cancer · Chemistry · Earth & Environmental Science · Genetics · Immunology · Life Sciences · Medicine & Health
Provenance · 1 source records, 12 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34027515 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[disease].local:disease:cancer | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[field].anzsrc:group:3105 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Genetics'] |
| concepts[field].anzsrc:group:3204 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Immunology'] |
| concepts[field].local:field:chemistry | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |